Akt1 and -2 inhibition diminishes terminal differentiation and enhances central memory CD8(+) T-cell proliferation and survival

The CD8(+) T-cell response comprises terminally differentiated effector cells and antigen-experienced memory T cells. The latter encompass central (T(CM)) and effector (T(EM)) memory cells. T(CM) cells are superior in their protection against viral and bacterial challenges and mediation of antitumor...

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Bibliographic Details
Published in:Oncoimmunology
Main Authors: Abu Eid, Rasha, Friedman, Kevin M, Mkrtichyan, Mikayel, Walens, Andrea, King, William, Janik, John, Khleif, Samir N
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485779/
https://ncbi.nlm.nih.gov/pubmed/26155399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1005448
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