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Cancer Cell–Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti–PD-1 Therapy in Lung Adenocarcinoma

MHC class II (MHCII) expression is usually restricted to APC but can be expressed by cancer cells. We examined the effect of cancer cell–specific MHCII (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti–PD-1 therapy using two orthotopic immunocompetent m...

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Detaylı Bibliyografya
Yayımlandı:J Immunol
Asıl Yazarlar: Johnson, Amber M., Bullock, Bonnie L., Neuwelt, Alexander J., Poczobutt, Joanna M., Kaspar, Rachael E., Li, Howard Y., Kwak, Jeff W., Hopp, Katharina, Weiser-Evans, Mary C. M., Heasley, Lynn E., Schenk, Erin L., Clambey, Eric T., Nemenoff, Raphael A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472648/
https://ncbi.nlm.nih.gov/pubmed/32179637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900778
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