Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II

Lung-specific overexpression of prostacyclin synthase (PGIS) decreases tumor initiation in murine lung cancer models. Prostacyclin analogs prevent lung tumor formation in mice and reverse bronchial dysplasia in former smokers. However, the effect of prostacyclin on lung cancer progression has not be...

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncoimmunology
Auteurs principaux: Li, Howard Y., McSharry, Maria, Walker, Deandra, Johnson, Amber, Kwak, Jeff, Bullock, Bonnie, Neuwelt, Alexander, Poczobutt, Joanna M., Sippel, Trisha R., Keith, Robert L., Weiser-Evans, Mary C. M., Clambey, Eric, Nemenoff, Raphael A.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927539/
https://ncbi.nlm.nih.gov/pubmed/29721380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1423182
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