Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II

Lung-specific overexpression of prostacyclin synthase (PGIS) decreases tumor initiation in murine lung cancer models. Prostacyclin analogs prevent lung tumor formation in mice and reverse bronchial dysplasia in former smokers. However, the effect of prostacyclin on lung cancer progression has not be...

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Bibliografski detalji
Izdano u:Oncoimmunology
Glavni autori: Li, Howard Y., McSharry, Maria, Walker, Deandra, Johnson, Amber, Kwak, Jeff, Bullock, Bonnie, Neuwelt, Alexander, Poczobutt, Joanna M., Sippel, Trisha R., Keith, Robert L., Weiser-Evans, Mary C. M., Clambey, Eric, Nemenoff, Raphael A.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927539/
https://ncbi.nlm.nih.gov/pubmed/29721380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1423182
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