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Targeted overexpression of prostacyclin synthase inhibits lung tumor progression by recruiting CD4+ T lymphocytes in tumors that express MHC class II

Lung-specific overexpression of prostacyclin synthase (PGIS) decreases tumor initiation in murine lung cancer models. Prostacyclin analogs prevent lung tumor formation in mice and reverse bronchial dysplasia in former smokers. However, the effect of prostacyclin on lung cancer progression has not be...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Li, Howard Y., McSharry, Maria, Walker, Deandra, Johnson, Amber, Kwak, Jeff, Bullock, Bonnie, Neuwelt, Alexander, Poczobutt, Joanna M., Sippel, Trisha R., Keith, Robert L., Weiser-Evans, Mary C. M., Clambey, Eric, Nemenoff, Raphael A.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927539/
https://ncbi.nlm.nih.gov/pubmed/29721380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1423182
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