Cancer Cell–Intrinsic Expression of MHC Class II Regulates the Immune Microenvironment and Response to Anti–PD-1 Therapy in Lung Adenocarcinoma

MHC class II (MHCII) expression is usually restricted to APC but can be expressed by cancer cells. We examined the effect of cancer cell–specific MHCII (csMHCII) expression in lung adenocarcinoma on T cell recruitment to tumors and response to anti–PD-1 therapy using two orthotopic immunocompetent m...

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Vydáno v:J Immunol
Hlavní autoři: Johnson, Amber M., Bullock, Bonnie L., Neuwelt, Alexander J., Poczobutt, Joanna M., Kaspar, Rachael E., Li, Howard Y., Kwak, Jeff W., Hopp, Katharina, Weiser-Evans, Mary C. M., Heasley, Lynn E., Schenk, Erin L., Clambey, Eric T., Nemenoff, Raphael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472648/
https://ncbi.nlm.nih.gov/pubmed/32179637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900778
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