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Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model

BACKGROUND: Emphysema is a crucial pathological characteristic of chronic obstructive pulmonary disease (COPD). Oxidative stress, apoptosis and epigenetic mechanisms contribute to the pathogenesis of emphysema. However, an attempt to accurately identify whether these mechanisms interact with each ot...

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Pubblicato in:Respir Res
Autori principali: Zeng, Huihui, Li, Tiao, He, Xue, Cai, Shan, Luo, Hong, Chen, Ping, Chen, Yan
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469342/
https://ncbi.nlm.nih.gov/pubmed/32883320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-020-01495-w
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