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The operational model of allosteric modulation of pharmacological agonism
Proper determination of agonist efficacy is indispensable in the evaluation of agonist selectivity and bias to activation of specific signalling pathways. The operational model (OM) of pharmacological agonism is a useful means for achieving this goal. Allosteric ligands bind to receptors at sites th...
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| Publicado en: | Sci Rep |
|---|---|
| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7468285/ https://ncbi.nlm.nih.gov/pubmed/32879329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71228-y |
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