Electric Field Measurements Reveal the Pivotal Role of Cofactor–Substrate Interaction in Dihydrofolate Reductase Catalysis

[Image: see text] The contribution of ligand–ligand electrostatic interaction to transition state formation during enzyme catalysis has remained unexplored, even though electrostatic forces are known to play a major role in protein functions and have been investigated by the vibrational Stark effect...

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Bibliografiska uppgifter
I publikationen:ACS Catal
Huvudupphovsmän: Adesina, Aduragbemi S., Świderek, Katarzyna, Luk, Louis Y. P., Moliner, Vicent, Allemann, Rudolf K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2020
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467645/
https://ncbi.nlm.nih.gov/pubmed/32905264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.0c01856
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