Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production of mucosal immunity-enhancing cytokines (e.g.,...

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Vydáno v:Microorganisms
Hlavní autoři: Yoshii, Ken, Hosomi, Koji, Shimoyama, Atsushi, Wang, Yunru, Yamaura, Haruki, Nagatake, Takahiro, Suzuki, Hidehiko, Lan, Huangwenxian, Kiyono, Hiroshi, Fukase, Koichi, Kunisawa, Jun
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464877/
https://ncbi.nlm.nih.gov/pubmed/32718009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8081102
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