Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production of mucosal immunity-enhancing cytokines (e.g.,...

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Publicado en:Microorganisms
Main Authors: Yoshii, Ken, Hosomi, Koji, Shimoyama, Atsushi, Wang, Yunru, Yamaura, Haruki, Nagatake, Takahiro, Suzuki, Hidehiko, Lan, Huangwenxian, Kiyono, Hiroshi, Fukase, Koichi, Kunisawa, Jun
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464877/
https://ncbi.nlm.nih.gov/pubmed/32718009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8081102
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