Chemically Synthesized Alcaligenes Lipid A Shows a Potent and Safe Nasal Vaccine Adjuvant Activity for the Induction of Streptococcus pneumoniae-Specific IgA and Th17 Mediated Protective Immunity

Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production of mucosal immunity-enhancing cytokines (e.g.,...

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Veröffentlicht in:Microorganisms
Hauptverfasser: Yoshii, Ken, Hosomi, Koji, Shimoyama, Atsushi, Wang, Yunru, Yamaura, Haruki, Nagatake, Takahiro, Suzuki, Hidehiko, Lan, Huangwenxian, Kiyono, Hiroshi, Fukase, Koichi, Kunisawa, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464877/
https://ncbi.nlm.nih.gov/pubmed/32718009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/microorganisms8081102
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