Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we reported that C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) targeted...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Suzuki, Hidehiko, Nagatake, Takahiro, Nasu, Ayaka, Lan, Huangwenxian, Ikegami, Koji, Setou, Mitsutoshi, Hamazaki, Yoko, Kiyono, Hiroshi, Yagi, Kiyohito, Kondoh, Masuo, Kunisawa, Jun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811541/
https://ncbi.nlm.nih.gov/pubmed/29440671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21120-7
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