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Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we reported that C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) targeted...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Suzuki, Hidehiko, Nagatake, Takahiro, Nasu, Ayaka, Lan, Huangwenxian, Ikegami, Koji, Setou, Mitsutoshi, Hamazaki, Yoko, Kiyono, Hiroshi, Yagi, Kiyohito, Kondoh, Masuo, Kunisawa, Jun
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811541/
https://ncbi.nlm.nih.gov/pubmed/29440671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21120-7
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