Impaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice

Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we reported that C-terminal fragment of Clostridium perfringens enterotoxin (C-CPE) targeted...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Suzuki, Hidehiko, Nagatake, Takahiro, Nasu, Ayaka, Lan, Huangwenxian, Ikegami, Koji, Setou, Mitsutoshi, Hamazaki, Yoko, Kiyono, Hiroshi, Yagi, Kiyohito, Kondoh, Masuo, Kunisawa, Jun
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811541/
https://ncbi.nlm.nih.gov/pubmed/29440671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21120-7
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