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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation

A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b and 18a–18h) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ(1–42) aggregation as potential treatments for Alzheimer’s disease (AD). In vitro studies identified the most...

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Vydáno v:	Molecules
Hlavní autoři:	Bowroju, Suresh K., Mainali, Nirjal, Ayyadevara, Srinivas, Penthala, Narsimha R., Krishnamachari, Sesha, Kakraba, Samuel, Reis, Robert J. Shmookler, Crooks, Peter A.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI 2020
Témata:	Article
On-line přístup:	https://ncbi.nlm.nih.gov/pmc/articles/PMC7463714/ https://ncbi.nlm.nih.gov/pubmed/32784464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163610
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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation

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