A Novel Microtubule-Binding Drug Attenuates and Reverses Protein Aggregation in Animal Models of Alzheimer’s Disease

Age-progressive neurodegenerative pathologies, including Alzheimer’s disease (AD), are distinguished and diagnosed by disease-specific components of intra- or extra-cellular aggregates. Increasing evidence suggests that neuroinflammation promotes protein aggregation, and is involved in the etiology...

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Autores principales: Samuel Kakraba, Srinivas Ayyadevara, Narsimha Reddy Penthala, Meenakshisundaram Balasubramaniam, Akshatha Ganne, Ling Liu, Ramani Alla, Shoban Babu Bommagani, Steven W. Barger, W. Sue T. Griffin, Peter A. Crooks, Robert J. Shmookler Reis
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019-12-01
Colección:Frontiers in Molecular Neuroscience
Materias:
Alzheimer’s disease
protein aggregation
GFAP (Glial Fibrillary Acidic Protein)
tubulin
combretastatin
anti-aggregant activity
Acceso en línea:https://www.frontiersin.org/article/10.3389/fnmol.2019.00310/full
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