Aggregate Interactome Based on Protein Cross-linking Interfaces Predicts Drug Targets to Limit Aggregation in Neurodegenerative Diseases

Diagnosis of neurodegenerative diseases hinges on “seed” proteins detected in disease-specific aggregates. These inclusions contain diverse constituents, adhering through aberrant interactions that our prior data indicate are nonrandom. To define preferential protein-protein contacts mediating aggre...

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Vydáno v:iScience
Hlavní autoři: Balasubramaniam, Meenakshisundaram, Ayyadevara, Srinivas, Ganne, Akshatha, Kakraba, Samuel, Penthala, Narsimha Reddy, Du, Xiuxia, Crooks, Peter A., Griffin, Sue T., Shmookler Reis, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6817627/
https://ncbi.nlm.nih.gov/pubmed/31593839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.09.026
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