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Design and Synthesis of Novel Hybrid 8-Hydroxy Quinoline-Indole Derivatives as Inhibitors of Aβ Self-Aggregation and Metal Chelation-Induced Aβ Aggregation
A series of novel hybrid 8-hydroxyquinoline-indole derivatives (7a–7e, 12a–12b and 18a–18h) were synthesized and screened for inhibitory activity against self-induced and metal-ion induced Aβ(1–42) aggregation as potential treatments for Alzheimer’s disease (AD). In vitro studies identified the most...
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| 出版年: | Molecules |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
MDPI
2020
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7463714/ https://ncbi.nlm.nih.gov/pubmed/32784464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25163610 |
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