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Structural modeling of GSK3β implicates the inactive (DFG-out) conformation as the target bound by TDZD analogs
Glycogen synthase kinase-3β (GSK3β) controls many physiological pathways, and is implicated in many diseases including Alzheimer’s and several cancers. GSK3β-mediated phosphorylation of target residues in microtubule-associated protein tau (MAPTAU) contributes to MAPTAU hyperphosphorylation and subs...
Kaydedildi:
| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7591898/ https://ncbi.nlm.nih.gov/pubmed/33110096 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-75020-w |
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