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MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by emergence of chemoresistant disease. To study roles for MYCN amplification in SCLC progression and chemoresistance, we developed a genetically engineered mouse model of MYCN-ove...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Genes Dev
Main Authors: Grunblatt, Eli, Wu, Nan, Zhang, Huajia, Liu, Xiaoli, Norton, Justin P., Ohol, Yamini, Leger, Paul, Hiatt, Joseph B., Eastwood, Emily C., Thomas, Rhiana, Ibrahim, Ali H., Jia, Deshui, Basom, Ryan, Eaton, Keith D., Martins, Renato, Houghton, A. McGarry, MacPherson, David
פורמט: Artigo
שפה:Inglês
יצא לאור: Cold Spring Harbor Laboratory Press 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462062/
https://ncbi.nlm.nih.gov/pubmed/32820040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340133.120
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