MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity

Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer characterized by initial chemosensitivity followed by emergence of chemoresistant disease. To study roles for MYCN amplification in SCLC progression and chemoresistance, we developed a genetically engineered mouse model of MYCN-ove...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Grunblatt, Eli, Wu, Nan, Zhang, Huajia, Liu, Xiaoli, Norton, Justin P., Ohol, Yamini, Leger, Paul, Hiatt, Joseph B., Eastwood, Emily C., Thomas, Rhiana, Ibrahim, Ali H., Jia, Deshui, Basom, Ryan, Eaton, Keith D., Martins, Renato, Houghton, A. McGarry, MacPherson, David
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462062/
https://ncbi.nlm.nih.gov/pubmed/32820040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340133.120
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