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A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence
The most frequent focal alterations in human retinoblastoma are mutations in the tumor-suppressor gene retinoblastoma (RB) and amplification of the oncogene MYCN. Whether MYCN overexpression drives retinoblastoma has not been assessed in model systems. Here, we have shown that Rb inactivation collab...
Sparad:
| I publikationen: | J Clin Invest |
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| Huvudupphovsmän: | , , , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
American Society for Clinical Investigation
2017
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5330763/ https://ncbi.nlm.nih.gov/pubmed/28165337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88508 |
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