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A mouse model of MYCN-driven retinoblastoma reveals MYCN-independent tumor reemergence
The most frequent focal alterations in human retinoblastoma are mutations in the tumor-suppressor gene retinoblastoma (RB) and amplification of the oncogene MYCN. Whether MYCN overexpression drives retinoblastoma has not been assessed in model systems. Here, we have shown that Rb inactivation collab...
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| Pubblicato in: | J Clin Invest |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5330763/ https://ncbi.nlm.nih.gov/pubmed/28165337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88508 |
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