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Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas

Small cell lung carcinoma (SCLC) is among the most lethal of all solid tumor malignancies. In an effort to identify novel therapeutic approaches for this recalcitrant cancer type, we applied genome-scale CRISPR/Cas9 inactivation screens to cell lines that we derived from a murine model of SCLC. SCLC...

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書目詳細資料
發表在:Genes Dev
Main Authors: Norton, Justin P., Augert, Arnaud, Eastwood, Emily, Basom, Ryan, Rudin, Charles M., MacPherson, David
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2021
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168556/
https://ncbi.nlm.nih.gov/pubmed/34016692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.348316.121
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