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Protein neddylation as a therapeutic target in pulmonary and extrapulmonary small cell carcinomas

Small cell lung carcinoma (SCLC) is among the most lethal of all solid tumor malignancies. In an effort to identify novel therapeutic approaches for this recalcitrant cancer type, we applied genome-scale CRISPR/Cas9 inactivation screens to cell lines that we derived from a murine model of SCLC. SCLC...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Norton, Justin P., Augert, Arnaud, Eastwood, Emily, Basom, Ryan, Rudin, Charles M., MacPherson, David
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2021
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8168556/
https://ncbi.nlm.nih.gov/pubmed/34016692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.348316.121
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