Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

Small cell lung cancer (SCLC) is a recalcitrant, aggressive neuroendocrine-type cancer for which little change to first-line, standard of care treatment has occurred within the last few decades. Unlike nonsmall cell lung cancer (NSCLC), SCLC harbors few actionable mutations for therapeutic intervent...

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Détails bibliographiques
Publié dans:Sci Signal
Auteurs principaux: Augert, Arnaud, Eastwood, Emily, Ibrahim, Ali H., Wu, Nan, Grunblatt, Eli, Basom, Ryan, Liggitt, Denny, Eaton, Keith D, Martins, Renato, Poirier, John T., Rudin, Charles M., Milletti, Francesca, Cheng, Wei-Yi, Mack, Fiona, MacPherson, David
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6530478/
https://ncbi.nlm.nih.gov/pubmed/30723171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aau2922
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