Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition

CREBBP, encoding an acetyltransferase, is among the most frequently mutated genes in small cell lung cancer (SCLC), a deadly neuroendocrine tumor type. We report acceleration of SCLC upon Crebbp inactivation in an autochthonous mouse model. Extending these observations beyond the lung, broad Crebbp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Discov
Prif Awduron: Jia, Deshui, Augert, Arnaud, Kim, Dong-Wook, Eastwood, Emily, Wu, Nan, Ibrahim, Ali H., Kim, Kee-Beom, Dunn, Colin T., Pillai, Smitha P.S., Gazdar, Adi F., Bolouri, Hamid, Park, Kwon-Sik, MacPherson, David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294438/
https://ncbi.nlm.nih.gov/pubmed/30181244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0385
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