Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition

CREBBP, encoding an acetyltransferase, is among the most frequently mutated genes in small cell lung cancer (SCLC), a deadly neuroendocrine tumor type. We report acceleration of SCLC upon Crebbp inactivation in an autochthonous mouse model. Extending these observations beyond the lung, broad Crebbp...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Jia, Deshui, Augert, Arnaud, Kim, Dong-Wook, Eastwood, Emily, Wu, Nan, Ibrahim, Ali H., Kim, Kee-Beom, Dunn, Colin T., Pillai, Smitha P.S., Gazdar, Adi F., Bolouri, Hamid, Park, Kwon-Sik, MacPherson, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6294438/
https://ncbi.nlm.nih.gov/pubmed/30181244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0385
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados