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The Different Ways through Which Specificity Works in Orthosteric and Allosteric Drugs

Currently, there are two types of drugs on the market: orthosteric, which bind at the active site; and allosteric, which bind elsewhere on the protein surface, and allosterically change the conformation of the protein binding site. In this perspective we argue that the different mechanisms through w...

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Detalles Bibliográficos
Publicado en:Curr Pharm Des
Main Authors: Nussinov, Ruth, Tsai, Chung-Jung
Formato: Artigo
Idioma:Inglês
Publicado: 2012
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458136/
https://ncbi.nlm.nih.gov/pubmed/22316155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/138161212799436377
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