XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition

Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. Previously, XRN2 was implicated in DNA double strand break (DSB) rep...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Patidar, Praveen L., Viera, Talysa, Morales, Julio C., Singh, Naveen, Motea, Edward A., Khandelwal, Megha, Fattah, Farjana J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455564/
https://ncbi.nlm.nih.gov/pubmed/32859985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71203-7
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