The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair

Ku70-binding protein 5 (Kub5)-Hera (K-H)/RPRD1B maintains genetic integrity by concomitantly minimizing persistent R-loops and promoting repair of DNA double strand breaks (DSBs). We used tandem affinity purification-mass spectrometry, co-immunoprecipitation and gel-filtration chromatography to defi...

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Udgivet i:Nucleic Acids Res
Main Authors: Patidar, Praveen L., Motea, Edward A., Fattah, Farjana J., Zhou, Yunyun, Morales, Julio C., Xie, Yang, Garner, Harold R., Boothman, David A.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2016
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770225/
https://ncbi.nlm.nih.gov/pubmed/26819409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1492
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