Kub5-Hera(RPRD1B) deficiency promotes “BRCAness” and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers

PURPOSE: Identification of novel strategies to expand the use of PARP inhibitors beyond BRCA deficiency is of great interest in personalized medicine. Here, we investigated the unannotated role of Kub5-Hera(RPRD1B) in homologous recombination (HR) repair and its potential clinical significance in ta...

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Bibliografske podrobnosti
izdano v:Clin Cancer Res
Main Authors: Motea, Edward A., Fattah, Farjana J., Xiao, Ling, Girard, Luc, Rommel, Amy, Morales, Julio C., Patidar, Praveen L., Zhou, Yunyun, Porter, Andrew C., Xie, Yang, Minna, John D., Boothman, David A.
Format: Artigo
Jezik:Inglês
Izdano: 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295248/
https://ncbi.nlm.nih.gov/pubmed/30108102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1118
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