Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

BACKGROUND: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exce...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Oncotarget
मुख्य लेखकों: Oei, Arlene L., van Leeuwen, Caspar M., Ahire, Vidhula R., Rodermond, Hans M., Cate, Rosemarie ten, Westermann, Anneke M., Stalpers, Lukas J.A., Crezee, Johannes, Petra Kok, H., Krawczyk, Przemek M., Kanaar, Roland, Franken, Nicolaas A.P.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Impact Journals LLC 2017
विषय:
Research Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438635/
https://ncbi.nlm.nih.gov/pubmed/28427225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15922
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