Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

BACKGROUND: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exce...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Oei, Arlene L., van Leeuwen, Caspar M., Ahire, Vidhula R., Rodermond, Hans M., Cate, Rosemarie ten, Westermann, Anneke M., Stalpers, Lukas J.A., Crezee, Johannes, Petra Kok, H., Krawczyk, Przemek M., Kanaar, Roland, Franken, Nicolaas A.P.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438635/
https://ncbi.nlm.nih.gov/pubmed/28427225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15922
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars