A carregar...

Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

BACKGROUND: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exce...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Oei, Arlene L., van Leeuwen, Caspar M., Ahire, Vidhula R., Rodermond, Hans M., Cate, Rosemarie ten, Westermann, Anneke M., Stalpers, Lukas J.A., Crezee, Johannes, Petra Kok, H., Krawczyk, Przemek M., Kanaar, Roland, Franken, Nicolaas A.P.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438635/
https://ncbi.nlm.nih.gov/pubmed/28427225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15922
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!