Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

BACKGROUND: Poly-(ADP-ribose)-polymerase1 (PARP1) is involved in repair of DNA single strand breaks. PARP1-inhibitors (PARP1-i) cause an accumulation of DNA double strand breaks, which are generally repaired by homologous recombination (HR). Therefore, cancer cells harboring HR deficiencies are exce...

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Pubblicato in:Oncotarget
Autori principali: Oei, Arlene L., van Leeuwen, Caspar M., Ahire, Vidhula R., Rodermond, Hans M., Cate, Rosemarie ten, Westermann, Anneke M., Stalpers, Lukas J.A., Crezee, Johannes, Petra Kok, H., Krawczyk, Przemek M., Kanaar, Roland, Franken, Nicolaas A.P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438635/
https://ncbi.nlm.nih.gov/pubmed/28427225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15922
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