Sensitizing thermochemotherapy with a PARP1-inhibitor

Cis-diamminedichloroplatinum(II) (cisplatin, cDDP) is an effective chemotherapeutic agent that induces DNA double strand breaks (DSBs), primarily in replicating cells. Generally, such DSBs can be repaired by the classical or backup non-homologous end joining (c-NHEJ/b-NHEJ) or homologous recombinati...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Oei, Arlene L, Vriend, Lianne E.M, van Leeuwen, Caspar M., Rodermond, Hans M, Cate, Rosemarie ten, Westermann, Anneke M, Stalpers, Lukas J.A., Crezee, Johannes, Kanaar, Roland, Petra, Kok H., Krawczyk, Przemek M, Franken, Nicolaas A.P.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5369964/
https://ncbi.nlm.nih.gov/pubmed/27557507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11422
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