Kub5-Hera(RPRD1B) deficiency promotes “BRCAness” and vulnerability to PARP inhibition in BRCA-proficient Breast Cancers

PURPOSE: Identification of novel strategies to expand the use of PARP inhibitors beyond BRCA deficiency is of great interest in personalized medicine. Here, we investigated the unannotated role of Kub5-Hera(RPRD1B) in homologous recombination (HR) repair and its potential clinical significance in ta...

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Udgivet i:Clin Cancer Res
Main Authors: Motea, Edward A., Fattah, Farjana J., Xiao, Ling, Girard, Luc, Rommel, Amy, Morales, Julio C., Patidar, Praveen L., Zhou, Yunyun, Porter, Andrew C., Xie, Yang, Minna, John D., Boothman, David A.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295248/
https://ncbi.nlm.nih.gov/pubmed/30108102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1118
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