XRN2 Links Transcription Termination to DNA Damage and Replication Stress

XRN2 is a 5’-3’ exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop structures and prevention of DNA double-strand breaks (DSBs). We show that XRN2 undergoes DNA damage-inducible nuclear re...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Morales, Julio C., Richard, Patricia, Patidar, Praveen L., Motea, Edward A., Dang, Tuyen T., Manley, James L., Boothman, David A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954731/
https://ncbi.nlm.nih.gov/pubmed/27437695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006107
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