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XRN2 Links Transcription Termination to DNA Damage and Replication Stress
XRN2 is a 5’-3’ exoribonuclease implicated in transcription termination. Here we demonstrate an unexpected role for XRN2 in the DNA damage response involving resolution of R-loop structures and prevention of DNA double-strand breaks (DSBs). We show that XRN2 undergoes DNA damage-inducible nuclear re...
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| 出版年: | PLoS Genet |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4954731/ https://ncbi.nlm.nih.gov/pubmed/27437695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006107 |
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