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XRN2 interactome reveals its synthetic lethal relationship with PARP1 inhibition
Persistent R-loops (RNA–DNA hybrids with a displaced single-stranded DNA) create DNA damage and lead to genomic instability. The 5′-3′-exoribonuclease 2 (XRN2) degrades RNA to resolve R-loops and promotes transcription termination. Previously, XRN2 was implicated in DNA double strand break (DSB) rep...
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| Publicado en: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7455564/ https://ncbi.nlm.nih.gov/pubmed/32859985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71203-7 |
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