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Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition
Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have somatic inactivating mutations in the BAP1 gene. BAP1 is a homologous recombination (HR) DNA...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer Berlin Heidelberg
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5608777/ https://ncbi.nlm.nih.gov/pubmed/28756516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3401-y |
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