Synthetic lethality in malignant pleural mesothelioma with PARP1 inhibition

Malignant pleural mesotheliomas (MPM) are most often surgically unresectable, and they respond poorly to current chemotherapy and radiation therapy. Between 23 and 64% of malignant pleural mesothelioma have somatic inactivating mutations in the BAP1 gene. BAP1 is a homologous recombination (HR) DNA...

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Detaylı Bibliyografya
Yayımlandı:Cancer Chemother Pharmacol
Asıl Yazarlar: Srinivasan, Gayathri, Sidhu, Gurjit Singh, Williamson, Elizabeth A., Jaiswal, Aruna S., Najmunnisa, Nasreen, Wilcoxen, Keith, Jones, Dennie, George, Thomas J., Hromas, Robert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer Berlin Heidelberg 2017
Konular:
Short Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608777/
https://ncbi.nlm.nih.gov/pubmed/28756516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3401-y
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