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MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers
Defects in DNA repair give rise to genomic instability, leading to neoplasia. Cancer cells defective in one DNA repair pathway can become reliant on remaining repair pathways for survival and proliferation. This attribute of cancer cells can be exploited therapeutically, by inhibiting the remaining...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6717293/ https://ncbi.nlm.nih.gov/pubmed/31395736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903150116 |
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