Microdissected pancreatic cancer proteomes reveal tumor heterogeneity and therapeutic targets

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a relative paucity of cancer cells that are surrounded by an abundance of nontumor cells and extracellular matrix, known as stroma. The interaction between stroma and cancer cells contributes to poor outcome, but how proteins from these ind...

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Pubblicato in:JCI Insight
Autori principali: Le Large, Tessa Y.S., Mantini, Giulia, Meijer, Laura L., Pham, Thang V., Funel, Niccola, van Grieken, Nicole C.T., Kok, Bart, Knol, Jaco, van Laarhoven, Hanneke W.M., Piersma, Sander R., Jimenez, Connie R., Kazemier, G., Giovannetti, Elisa, Bijlsma, Maarten F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455080/
https://ncbi.nlm.nih.gov/pubmed/32634123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.138290
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