Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment

BACKGROUND: Chemoresistance hampers the treatment of patients suffering from pancreatic ductal adenocarcinoma (PDAC). Here we aimed to evaluate the (phospho)proteome of gemcitabine-sensitive and gemcitabine-resistant PDAC cells to identify novel therapeutic targets and predictive biomarkers. METHODS...

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Detalhes bibliográficos
Publicado no:Ther Adv Med Oncol
Main Authors: Le Large, Tessa Ya Sung, El Hassouni, Btissame, Funel, Niccola, Kok, Bart, Piersma, Sander R., Pham, Thang V., Olive, Kenneth P., Kazemier, Geert, van Laarhoven, Hanneke W.M., Jimenez, Connie R., Bijlsma, Maarten F., Giovannetti, Elisa
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535709/
https://ncbi.nlm.nih.gov/pubmed/31205498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835919841233
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