Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment

BACKGROUND: Chemoresistance hampers the treatment of patients suffering from pancreatic ductal adenocarcinoma (PDAC). Here we aimed to evaluate the (phospho)proteome of gemcitabine-sensitive and gemcitabine-resistant PDAC cells to identify novel therapeutic targets and predictive biomarkers. METHODS...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Ther Adv Med Oncol
Egile Nagusiak: Le Large, Tessa Ya Sung, El Hassouni, Btissame, Funel, Niccola, Kok, Bart, Piersma, Sander R., Pham, Thang V., Olive, Kenneth P., Kazemier, Geert, van Laarhoven, Hanneke W.M., Jimenez, Connie R., Bijlsma, Maarten F., Giovannetti, Elisa
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: SAGE Publications 2019
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535709/
https://ncbi.nlm.nih.gov/pubmed/31205498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835919841233
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