Proteomic analysis of gemcitabine-resistant pancreatic cancer cells reveals that microtubule-associated protein 2 upregulation associates with taxane treatment

BACKGROUND: Chemoresistance hampers the treatment of patients suffering from pancreatic ductal adenocarcinoma (PDAC). Here we aimed to evaluate the (phospho)proteome of gemcitabine-sensitive and gemcitabine-resistant PDAC cells to identify novel therapeutic targets and predictive biomarkers. METHODS...

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Veröffentlicht in:Ther Adv Med Oncol
Hauptverfasser: Le Large, Tessa Ya Sung, El Hassouni, Btissame, Funel, Niccola, Kok, Bart, Piersma, Sander R., Pham, Thang V., Olive, Kenneth P., Kazemier, Geert, van Laarhoven, Hanneke W.M., Jimenez, Connie R., Bijlsma, Maarten F., Giovannetti, Elisa
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2019
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6535709/
https://ncbi.nlm.nih.gov/pubmed/31205498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835919841233
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