Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is regulated by phosphorylation. We investigated phosphorylated kinases as target in PDAC. METHODS: Mass spectrometry-based ph...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Exp Clin Cancer Res
Auteurs principaux: Le Large, T. Y. S., Bijlsma, M. F., El Hassouni, B., Mantini, G., Lagerweij, T., Henneman, A. A., Funel, N., Kok, B., Pham, T. V., de Haas, R., Morelli, L., Knol, J. C., Piersma, S. R., Kazemier, G., van Laarhoven, H. W. M., Giovannetti, E., Jimenez, C. R.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2021
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7941981/
https://ncbi.nlm.nih.gov/pubmed/33750427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-01892-z
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