Defining the mutation signatures of DNA polymerase θ in cancer genomes

DNA polymerase theta (POLQ)-mediated end joining (TMEJ) is a distinct pathway for mediating DNA double-strand break (DSB) repair. TMEJ is required for the viability of BRCA-mutated cancer cells. It is crucial to identify tumors that rely on POLQ activity for DSB repair, because such tumors are defec...

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Detalhes bibliográficos
Publicado no:NAR Cancer
Main Authors: Hwang, Taejoo, Reh, Shelley, Dunbayev, Yerkin, Zhong, Yi, Takata, Yoko, Shen, Jianjun, McBride, Kevin M, Murnane, John P, Bhak, Jong, Lee, Semin, Wood, Richard D, Takata, Kei-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
DNA Damage Sensing and Repair
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454005/
https://ncbi.nlm.nih.gov/pubmed/32885167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa017
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