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Defining the mutation signatures of DNA polymerase θ in cancer genomes
DNA polymerase theta (POLQ)-mediated end joining (TMEJ) is a distinct pathway for mediating DNA double-strand break (DSB) repair. TMEJ is required for the viability of BRCA-mutated cancer cells. It is crucial to identify tumors that rely on POLQ activity for DSB repair, because such tumors are defec...
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| 發表在: | NAR Cancer |
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| Main Authors: | , , , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7454005/ https://ncbi.nlm.nih.gov/pubmed/32885167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa017 |
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