Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance

DNA polymerase ν (pol ν), encoded by the POLN gene, is an A-family DNA polymerase in vertebrates and some other animal lineages. Here we report an in-depth analysis of pol ν–defective mice and human cells. POLN is very weakly expressed in most tissues, with the highest relative expression in testis....

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Takata, Kei-ichi, Reh, Shelley, Yousefzadeh, Matthew J., Zelazowski, Maciej J., Bhetawal, Sarita, Trono, David, Lowery, Megan G., Sandoval, Maria, Takata, Yoko, Lu, Yue, Lin, Kevin, Shen, Jianjun, Kusewitt, Donna F., McBride, Kevin M., Cole, Francesca, Wood, Richard D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5472330/
https://ncbi.nlm.nih.gov/pubmed/28570559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006818
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