Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency

TP53 deficiency in cancer is associated with poor patient outcomes and resistance to DNA damaging therapies. However, the mechanisms underlying treatment resistance in p53-deficient cells remain poorly characterized. Using live cell imaging of DNA double-strand breaks (DSBs) and cell cycle state tra...

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Vydáno v:NAR Cancer
Hlavní autoři: Kumar, Rashmi J, Chao, Hui Xiao, Simpson, Dennis A, Feng, Wanjuan, Cho, Min-Guk, Roberts, Victoria R, Sullivan, Aurora R, Shah, Sonam J, Wozny, Anne-Sophie, Fagan-Solis, Katerina, Kumar, Sunil, Luthman, Adam, Ramsden, Dale A, Purvis, Jeremy E, Gupta, Gaorav P
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
DNA Damage Sensing and Repair
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7751686/
https://ncbi.nlm.nih.gov/pubmed/33385162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcaa038
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