Mechanistic basis for microhomology identification and genome scarring by polymerase theta

DNA polymerase theta mediates an end joining pathway (TMEJ) that repairs chromosome breaks. It requires resection of broken ends to generate long, 3′ single-stranded DNA tails, annealing of complementary sequence segments (microhomologies) in these tails, followed by microhomology-primed synthesis s...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Carvajal-Garcia, Juan, Cho, Jang-Eun, Carvajal-Garcia, Pablo, Feng, Wanjuan, Wood, Richard D., Sekelsky, Jeff, Gupta, Gaorav P., Roberts, Steven A., Ramsden, Dale A.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2020
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165422/
https://ncbi.nlm.nih.gov/pubmed/32234782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921791117
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