Mechanistic basis for microhomology identification and genome scarring by polymerase theta

DNA polymerase theta mediates an end joining pathway (TMEJ) that repairs chromosome breaks. It requires resection of broken ends to generate long, 3′ single-stranded DNA tails, annealing of complementary sequence segments (microhomologies) in these tails, followed by microhomology-primed synthesis s...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Carvajal-Garcia, Juan, Cho, Jang-Eun, Carvajal-Garcia, Pablo, Feng, Wanjuan, Wood, Richard D., Sekelsky, Jeff, Gupta, Gaorav P., Roberts, Steven A., Ramsden, Dale A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165422/
https://ncbi.nlm.nih.gov/pubmed/32234782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921791117
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