Mechanistic basis for microhomology identification and genome scarring by polymerase theta

DNA polymerase theta mediates an end joining pathway (TMEJ) that repairs chromosome breaks. It requires resection of broken ends to generate long, 3′ single-stranded DNA tails, annealing of complementary sequence segments (microhomologies) in these tails, followed by microhomology-primed synthesis s...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Carvajal-Garcia, Juan, Cho, Jang-Eun, Carvajal-Garcia, Pablo, Feng, Wanjuan, Wood, Richard D., Sekelsky, Jeff, Gupta, Gaorav P., Roberts, Steven A., Ramsden, Dale A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7165422/
https://ncbi.nlm.nih.gov/pubmed/32234782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1921791117
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