Negative selection of human T cells recognizing a naturally-expressed tissue-restricted antigen in the human thymus

During T cell development in mice, thymic negative selection deletes cells with the potential to recognize and react to self-antigens. In human T cell-dependent autoimmune diseases such as Type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, T cells reactive to autoantigens are thought to...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Transl Autoimmun
Auteurs principaux: Madley, Rachel, Nauman, Grace, Danzl, Nichole, Borsotti, Chiara, Khosravi Maharlooei, Mohsen, Li, Hao Wei, Chavez, Estefania, Creusot, Remi J., Nakayama, Maki, Roep, Bart, Sykes, Megan
Format: Artigo
Langue:Inglês
Publié: Elsevier 2020
Sujets:
Research paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451786/
https://ncbi.nlm.nih.gov/pubmed/32875283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtauto.2020.100061
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