Role of the thymus in spontaneous development of a multi-organ autoimmune disease in human immune system mice

We evaluated the role of the thymus in development of multi-organ autoimmunity in human immune system (HIS) mice. T cells were essential for disease development and the same T cell clones with varying phenotypes infiltrated multiple tissues. De novo-generated hematopoietic stem cell (HSC)-derived T...

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Pubblicato in:J Autoimmun
Autori principali: Khosravi-Maharlooei, Mohsen, Li, HaoWei, Hoelzl, Markus, Zhao, Guiling, Ruiz, Amanda, Misra, Aditya, Li, Yang, Teteloshvili, Nato, Nauman, Grace, Danzl, Nichole, Ding, Xiaolan, Pinker, Elisha Y, Obradovic, Aleksandar, Yang, Yong-Guang, Iuga, Alina, Creusot, Remi J, Winchester, Robert, Sykes, Megan
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044037/
https://ncbi.nlm.nih.gov/pubmed/33611150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2021.102612
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