Cross-reactive public TCR sequences undergo positive selection in the human thymic repertoire

We studied human T cell repertoire formation using high-throughput T cell receptor β (TCRβ) complementarity-determining region 3 (CDR3) sequencing in immunodeficient mice receiving human hematopoietic stem cells (HSCs) and human thymus grafts. Replicate humanized mice generated diverse and highly di...

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Vydáno v:J Clin Invest
Hlavní autoři: Khosravi-Maharlooei, Mohsen, Obradovic, Aleksandar, Misra, Aditya, Motwani, Keshav, Holzl, Markus, Seay, Howard R., DeWolf, Susan, Nauman, Grace, Danzl, Nichole, Li, Haowei, Ho, Siu-hong, Winchester, Robert, Shen, Yufeng, Brusko, Todd M., Sykes, Megan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6546456/
https://ncbi.nlm.nih.gov/pubmed/30920391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI124358
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