HSC extrinsic sex-related and intrinsic autoimmune disease–related human B-cell variation is recapitulated in humanized mice

B cells play a major role in antigen presentation and antibody production in the development of autoimmune diseases, and some of these diseases disproportionally occur in females. Moreover, immune responses tend to be stronger in female vs male humans and mice. Because it is challenging to distingui...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Borsotti, Chiara, Danzl, Nichole M., Nauman, Grace, Hölzl, Markus A., French, Clare, Chavez, Estefania, Khosravi-Maharlooei, Mohsen, Glauzy, Salome, Delmotte, Fabien R., Meffre, Eric, Savage, David G., Campbell, Sean R., Goland, Robin, Greenberg, Ellen, Bi, Jing, Satwani, Prakash, Yang, Suxiao, Bathon, Joan, Winchester, Robert, Sykes, Megan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728279/
https://ncbi.nlm.nih.gov/pubmed/29296847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006932
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