METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth

Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo screens to test 78 potential methyltransferases for...

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Publicat a:Sci Adv
Autors principals: Ignatova, Valentina V., Kaiser, Steffen, Ho, Jessica Sook Yuin, Bing, Xinyang, Stolz, Paul, Tan, Ying Xim, Lee, Chee Leng, Gay, Florence Pik Hoon, Lastres, Palma Rico, Gerlini, Raffaele, Rathkolb, Birgit, Aguilar-Pimentel, Antonio, Sanz-Moreno, Adrián, Klein-Rodewald, Tanja, Calzada-Wack, Julia, Ibragimov, Emil, Valenta, Magdalena, Lukauskas, Saulius, Pavesi, Andrea, Marschall, Susan, Leuchtenberger, Stefanie, Fuchs, Helmut, Gailus-Durner, Valerie, de Angelis, Martin Hrabe, Bultmann, Sebastian, Rando, Oliver J., Guccione, Ernesto, Kellner, Stefanie M., Schneider, Robert
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449687/
https://ncbi.nlm.nih.gov/pubmed/32923617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz4551
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